2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sodium Channel

Sodium Channel

Na channels; Na+ channels

Sodium Channel

Related Products

PDF 3.33 MB

Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.

Sodium Channel Isoform Specific Products:

Sodium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0185AS1
    Lidocaine-d6 hydrochloride
    		Inhibitor
    Lidocaine-d6 (hydrochloride) is deuterium labeled Lidocaine (hydrochloride). Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a agent to treat ventricular arrhythmia and an effective tumor-inhibitor.
    Lidocaine-d<sub>6</sub> hydrochloride
  • HY-P5816
    BmK-M1
    		Inhibitor
    BmK-M1 is a scorpion toxin, and is composed of 64 amino acids cross-linked by four disulfide bridges. BmK-M1 inhibits Na+ channel and can be considered both as a cardiotoxin and a neurotoxin.
    BmK-M1
  • HY-116436
    Clathrodin
    		Modulator
    Clathrodin is a marine alkaloid that can be isolated from sponges of the genus, Agelas. Clathrodin is a modulator of voltage-gated sodium (NaV) channels. Clathrodin is a sodium channel neurotoxin influencing sodium channel ionic conductance.
    Clathrodin
  • HY-B0517AR
    Mepivacaine hydrochloride (Standard)
    		Inhibitor
    Mepivacaine (hydrochloride) (Standard) is the analytical standard of Mepivacaine (hydrochloride). This product is intended for research and analytical applications. Mepivacaine hydrochloride binds to specific voltage-gated sodium ion channels in neuronal cell membranes, which inhibits both sodium influx and membrane depolarization.
    Mepivacaine hydrochloride (Standard)
  • HY-B0285AS
    Amiloride-15N3 hydrochloride
    Amiloride-15N3 (hydrochloride) is the 15N labeled Amiloride hydrochloride. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2) channel.
    Amiloride-<sup>15</sup>N<sub>3</sub> hydrochloride
  • HY-168988
    Olisutrigine bromide
    		Inhibitor
    Olisutrigine bromide is a sodium channel blocker, which can be used as analgesics.
    Olisutrigine bromide
  • HY-160208
    BI-8668
    		Inhibitor
    BI-8668 (compound 40), a chemical probe, is an inhibitor of ENaC. BI-8668 can be used in the study of cystic fibrosis.
    BI-8668
  • HY-177361
    Zocainone
    		Inhibitor
    Zocainone is an antiarrhythmic agent. Zocainone blocks sodium channels in cardiac tissue, stabilizing the cardiac action potential and reducing abnormal electrical activity. Zocainone is promising for research of cardiac arrhythmias.
    Zocainone
  • HY-B1139A
    Tolperisone
    Tolperisone, a centrally acting muscle relaxant, is utilized for alleviating symptoms of spasticity and muscle spasms.
    Tolperisone
  • HY-119980B
    Fluphenazine hydrochloride
    		Inhibitor
    Fluphenazine hydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine hydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine hydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine hydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine hydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2.
    Fluphenazine hydrochloride
  • HY-19679
    Quinacainol
    		Inhibitor
    Quinacainol (PK 10139) is an inhibitor for sodium current with an EC50 of 95 µM. Quinacainol exhibits antiarrhythmic activity by affecting the electrophysiological properties of the heart.
    Quinacainol
  • HY-A0042S1
    Rufinamide-15N,d2
    		Inhibitor
    Rufinamide-15N,d2 (CGP 33101-15N,d2) is the deuterium and 15N labeled Rufinamide (HY-A0042).Rufinamide (CGP 33101) is an orally active antiepileptic compound that inhibits Na+ current activation, inhibits neuronal hyperexcitability, and has anticonvulsant effects. Rufinamide is used in the study of Lennox-Gastaut syndrome.
    Rufinamide-<sup>15</sup>N,d<sub>2</sub>
  • HY-P5782
    δ-Theraphotoxin-Hm1a toxin
    		Activator
    δ-Theraphotoxin-Hm1a toxin is a selective Nav1.1 activator. δ-Theraphotoxin-Hm1a toxin elicits pain and touch sensitivity. δ-Theraphotoxin-Hm1a toxin can be used for the research of irritable bowel syndrome.
    δ-Theraphotoxin-Hm1a toxin
  • HY-177311
    NVP-QBE170
    		Inhibitor
    NVP-QBE170 is a selective Epithelial sodium channel (ENaC) inhibitor with an IC50 of 57.5 nM. NVP-QBE170 potently inhibits ENaC function in HBECs and shows a longer duration of action. NVP-QBE170 significantly attenuates ENaC activity in the airways of guinea pig models. NVP-QBE170 can be used for hyperkalaemia research.
    NVP-QBE170
  • HY-149994
    DS43260857
    		Inhibitor
    DS43260857 is a potentNaV1.7inhibitor, which has a high inhibitory effect on both human and mouse NaV1.7. The IC50 values of DS43260857 for hNaV1.1, hNaV1.5, hNaV1.7, mNaV1.7 are 6.6, 14, 0.015 and 0.061 μM, respectively.
    DS43260857
  • HY-P5807
    Cn2 toxin
    		Activator
    Cn2 toxin is aβ- toxoins. Cn2 toxin can bind to the voltage sensing domain of voltage gated sodium channels (Nav) .
    Cn2 toxin
  • HY-B1837R
    Cyfluthrin (Standard)
    		Inhibitor
    Cyfluthrin (Standard) is the analytical standard of Cyfluthrin. This product is intended for research and analytical applications. Cyfluthrin is a type II pyrethroid and has effects on various insects. Cyfluthrin is a modulator of Nav1.8 sodium channels by repetitive stimulation. Cyfluthrin can be applied in agriculture,veterinary, insecticide,pyrethroid and stored product[1][2].
    Cyfluthrin (Standard)
  • HY-P5160
    Phlotoxin-1
    		Inhibitor
    Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel.
    Phlotoxin-1
  • HY-12883B
    PF 05089771 tosylate
    		Inhibitor
    PF 05089771 tosylate is a potent, orally active and selective arylsulfonamide Nav1.7 inhibitor, with IC50 values of 11 nM, 12 nM, 13 nM, 171 nM and 8 nM for hNav1.7, cynNav1.7, dogNav1.7, ratNav1.7, and musNav1.7, respectively. PF 05089771 is under the study for pain and diabetic neuropathy.
    PF 05089771 tosylate
  • HY-172998
    Nav1.8-IN-18
    		Inhibitor
    Nav1.8-IN-19 (Compound 70) is a Nav1.8 inhibitor.
    Nav1.8-IN-18
Cat. No. Product Name / Synonyms Application Reactivity
Sodium Channel Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.